Credits

The KinATLAS KnowledgeBase webpages were designed by Dr. Steven Pelech and developed by Alireza Davoodi and Moein Enayati.

The experimental data on protein kinase – substrate protein interactions were retrieved from the Phosphosite Plus website produced by Cell Signaling Technology and by Dr. Steven Pelech from hundreds of original research publications. Predicted protein kinase-substrate protein interactions were determined using the Kinexus Kinase Substrate Predictor Version 2.0 algorithm developed by Dr. Javad Safaei and Dr. Steven Pelech. The protein-protein interaction data were retrieved by Dr. Javad Safaei from the STRING database (www.string.embl.de). STRING is a database of known and predicted protein-protein interactions that was produced by the Swiss Institute of Bioinformatics, the NNF Center for Protein Research and The European Molecular Biology Laboratory. The original raw mRNA expression data was originally retrieved from the National Centre for Biotechnology Information’s Gene Expression Omnibus (NCBI GEO).

The mRNA expression data was collated and normalized by Dr. Javad Safaei, Shabab Hoissain, and Dr. Jano Manuch in the Department of Computer Science at the University of British Columbia. The compound IC50, Ki and Kd data were retrieved from several sources, including the National Center for Biotechnology Information (NCBI), the PubChem Compound database, the Kinase SARfari database from the European Molecular Biology Laboratory (EMBL) European Bioinformatics Institute, the International Centre for Kinase Profiling at the University of Dundee, Ambit Biosciences and hundreds of original research publications. The kinase inhibitor data collection was performed by Sehyun Cho, Stephen Yiu, Chuen Choi, Pier-Luc Clemont, Christine Eisner, Dr. Steven Pelech, Cameron Rogers and Scott Wilder.

The kinase inhibitor prediction algorithms were developed and coded by Dr. Javad Safaei and Dr. Jano Manuch.  

Copyright 2019 Kinexus Bioinformatics Corporation